Anti Gout

Gout is a most common inflammatory joint disease in men and older women. It is most painful form of arthritis characterized by the formation of uric acid crystals and severe inflammation.

The term gout describes a disease spectrum includes hyperuricemia, recurrent attacks of acute arthritis associated with monosodium urate crystals in leukocytes found in synovial fluid, deposit of monosodium Urate crystals in tissues (tophi), interstitial renal disease and uric acid nephrolothiasis.

Hyperuricemia may be an asymptomatic condition with an increased serum uric acid concentration greater than 7.0 mg/dL is abnormal and associated with an increased risk for gout.

This occurs either due to
    1. Overproduction of uric acid
  • # defect in purine salvage pathway (hypoxanthine phosphoribosyltransferase deficiency)
  • # disease causing high cell turnover ( psoriasis)

    2. Under excretion of uric acid
  • # decreased glomerular filtration rate (GFL)
  • # impaired renal function
  • # Diuretics